abstract：:Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in...

journal_title：Molecular and cellular endocrinology

authors： Lammel Lindemann JA,Angajala A,Engler DA,Webb P,Ayers SD

更新日期：2014-05-05 00:00:00

abstract：:G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective ro...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Zhang Q,Yang L,Dong Y,Khan M,Yang F,Brann DW,Wang R

更新日期：2014-04-25 00:00:00

abstract：:Low-grade inflammation links obesity, insulin resistance, and cardiovascular diseases. We investigated the effects of laparoscopic sleeve gastrectomy (LSG) on expression profile of genes involved in inflammatory pathways in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM). At baseline, obese group had ...

journal_title：Molecular and cellular endocrinology

authors： Trachta P,Dostálová I,Haluzíková D,Kasalický M,Kaválková P,Drápalová J,Urbanová M,Lacinová Z,Mráz M,Haluzík M

更新日期：2014-03-05 00:00:00

abstract：:Valproic acid (VPA) has been shown to increase the reprogramming efficiency of induced pluripotent stem cells (iPSC) from somatic cells, but the mechanism by which VPA enhances iPSC induction has not been defined. Here we demonstrated that VPA directly activated Oct4 promoter activity through activation of the PI3K/Ak...

journal_title：Molecular and cellular endocrinology

authors： Teng HF,Li PN,Hou DR,Liu SW,Lin CT,Loo MR,Kao CH,Lin KH,Chen SL

更新日期：2014-03-05 00:00:00

abstract：:Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are widely recognized for their roles in ovulation and the support of early pregnancy. Aside from the timing of expression, however, the differences between LH and hCG have largely been overlooked in the clinical realm because of their similar molecular s...

journal_title：Molecular and cellular endocrinology

authors： Choi J,Smitz J

更新日期：2014-03-05 00:00:00

abstract：:Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant role in the progression of human prostate cancer (PCa), which is associated with heterogeneity of SSRs expression and specific cell localization as we already demonstrated in the LNCaP cell line, an in vitro model of hu...

journal_title：Molecular and cellular endocrinology

authors： Ruscica M,Magni P,Steffani L,Gatto F,Albertelli M,Rametta R,Valenti L,Ameri P,Magnaghi V,Culler MD,Minuto F,Ferone D,Arvigo M

更新日期：2014-02-15 00:00:00

abstract：:Wnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or absence of its activat...

journal_title：Molecular and cellular endocrinology

authors： Li L,Ji SY,Yang JL,Li XX,Zhang J,Zhang Y,Hu ZY,Liu YX

更新日期：2014-02-15 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:Advanced prostate cancers, initially sensitive to androgen deprivation therapy, frequently progress to the castration-resistant prostate cancer phenotype (CRPC) through mechanisms not yet fully understood. In this study we investigated mitochondrial involvement in the establishment of refractoriness to hormone therapy...

journal_title：Molecular and cellular endocrinology

authors： Pignatta S,Arienti C,Zoli W,Di Donato M,Castoria G,Gabucci E,Casadio V,Falconi M,De Giorgi U,Silvestrini R,Tesei A

更新日期：2014-01-25 00:00:00

abstract：:Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroe...

journal_title：Molecular and cellular endocrinology

authors： Vandenput L,Ohlsson C

更新日期：2014-01-25 00:00:00

abstract：:The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includ...

journal_title：Molecular and cellular endocrinology

authors： Zambrano E,Guzmán C,Rodríguez-González GL,Durand-Carbajal M,Nathanielsz PW

更新日期：2014-01-25 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR α and PPAR β/δ activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742-pharmacological activators of PPAR ...

journal_title：Molecular and cellular endocrinology

authors： Regueira M,Riera MF,Galardo MN,Pellizzari EH,Cigorraga SB,Meroni SB

更新日期：2014-01-25 00:00:00

abstract：:Mammalian α4 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase. This study showed induction of the EDD protein by progesterone, 17β-estradiol and prolactin in breast cancer cells....

journal_title：Molecular and cellular endocrinology

authors： McDonald WJ,Thomas LN,Koirala S,Too CKL

更新日期：2014-01-25 00:00:00

abstract：:Both constitutive and ligand-mediated membrane trafficking regulate Epidermal Growth Factor Receptor (EGFR) signaling. The constitutive endocytosis and recycling of the unliganded EGFR is a critical determinant of cell surface EGFR expression and the cell's sensitivity to ligands. We report that two proteins with esta...

journal_title：Molecular and cellular endocrinology

authors： Rush JS,Ceresa BP

更新日期：2013-12-05 00:00:00

abstract：:Human placenta produces melatonin and expresses its receptors. We propose that melatonin, an antioxidant, protects the human placenta against hypoxia/reoxygenation (H/R)-induced damage. Primary term villous cytotrophoblasts were cultured under normoxia (8% O2) with or without 1mM melatonin for 72h to induce differenti...

journal_title：Molecular and cellular endocrinology

authors： Lanoix D,Lacasse AA,Reiter RJ,Vaillancourt C

更新日期：2013-12-05 00:00:00

abstract：:Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role d...

journal_title：Molecular and cellular endocrinology

authors： Zhang XH,Liang X,Wang TS,Liang XH,Zuo RJ,Deng WB,Zhang ZR,Qin FN,Zhao ZA,Yang ZM

更新日期：2013-12-05 00:00:00

abstract：:Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a...

journal_title：Molecular and cellular endocrinology

authors： Dickmeis T,Weger BD,Weger M

更新日期：2013-11-05 00:00:00

abstract：:Endocrine dysfunction in mitochondrial disease is commonplace, but predominantly restricted to disease of the endocrine pancreas resulting in diabetes mellitus. Other endocrine manifestations occur, but are relatively rare by comparison. In mitochondrial disease, neuromuscular symptoms often dominate the clinical phen...

journal_title：Molecular and cellular endocrinology

authors： Schaefer AM,Walker M,Turnbull DM,Taylor RW

更新日期：2013-10-15 00:00:00

abstract：:The canonical renin-angiotensin system (RAS) involves the initial action of renin to cleave angiotensinogen to angiotensin I (ANG I), which is then converted to ANG II by the angiotensin converting enzyme (ACE). ANG II plays a critical role in numerous physiological functions, and RAS overactivity underlies many condi...

journal_title：Molecular and cellular endocrinology

authors： Henriksen EJ,Prasannarong M

更新日期：2013-09-25 00:00:00

abstract：:The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes. Important in this relationship is the strong correlation between hyperinsulinemia and low levels of albuminuria (e.g. microalbuminuria). Recent work highl...

journal_title：Molecular and cellular endocrinology

authors： Nistala R,Whaley-Connell A

更新日期：2013-09-25 00:00:00

abstract：:Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling path...

journal_title：Molecular and cellular endocrinology

authors： Schedlich LJ,Yenson VM,Baxter RC

更新日期：2013-09-05 00:00:00

abstract：:Vitamin D is a key factor for calcium and bone homeostasis, but signalling through the vitamin D receptor (VDR) seems also to be important for testicular function. To test the functional role of vitamin D signalling we examined the male reproductive system of the Leuven Vdr-ablated (Vdr(-/-)) mice, previously establis...

journal_title：Molecular and cellular endocrinology

authors： Blomberg Jensen M,Lieben L,Nielsen JE,Willems A,Jørgensen A,Juul A,Toppari J,Carmeliet G,Rajpert-De Meyts E

更新日期：2013-09-05 00:00:00

abstract：:Our previous study revealed the particular expression patterns of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 1 (IGFBP1) in the Qinghai-Tibet plateau root vole (Microtus oeconomus) under hypoxic challenge. Here we report the molecular mechanisms of Igf gene regulation associated ...

journal_title：Molecular and cellular endocrinology

authors： Zhang S,Zhao Y,Hu X,Liu Z,Chen X,Chen X,Du J

更新日期：2013-08-25 00:00:00

abstract：:Dual-specificity phosphatase 6 (Dusp6) is a negative feedback mechanism of fibroblast growth factors (FGFs)/mitogen-activated protein kinase (MAPK)/ERK1/2 signaling. The aim of this study was to explore the expression of Dusp6 in human endometrial adenocarcinomas and the role of Dusp6 expression in the growth regulati...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Guo Q,Wang C,Yan L,Fu Y,Fan M,Zhao X,Li M

更新日期：2013-08-25 00:00:00

abstract：:Cyclic ewes were treated with control vehicle or progesterone receptor antagonist (onapristone; 100mg i.m. twice daily) during either early (day 3-5) or late (day 12-14) luteal phase and plasma samples collected for hormone analysis and to determine endogenous and oxytocin induced PGF2α release. On day 14 and 17, ewes...

journal_title：Molecular and cellular endocrinology

authors： Mann GE,Wathes DC,Robinson RS

更新日期：2013-08-25 00:00:00

abstract：:Estrogen receptor β (ERβ) and its isoforms have different putative functions and expression patterns in prostate cancer. Current studies on 5'-most exons, 0K and 0N, show that their respective promoters are actively involved in transcription. These data, however, do not explain why ERβ isoforms are differentially expr...

journal_title：Molecular and cellular endocrinology

authors： Lee MT,Ouyang B,Ho SM,Leung YK

更新日期：2013-08-25 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor PAC1-R (PACAP type 1 receptor) are transiently expressed in granulosa cells (GCs) of mouse preovulatory follicles and affect several parameters associated with the ovulatory process. We investigated the expression of PACAP and its receptors in...

journal_title：Molecular and cellular endocrinology

authors： Barberi M,Di Paolo V,Latini S,Guglielmo MC,Cecconi S,Canipari R

更新日期：2013-08-15 00:00:00

abstract：:The members of stanniocalcins (STCs: STC-1 and STC-2) family are known to be involved in tumor progression and metastasis. Although current evidences suggest the involvement of STCs in vascular biology, the functional roles of STCs in angiogenesis have not yet been elucidated. The objective of this study was to deciph...

journal_title：Molecular and cellular endocrinology

authors： Law AY,Wong CK

更新日期：2013-07-15 00:00:00

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes,...

journal_title：Molecular and cellular endocrinology

authors： Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DA

更新日期：2013-07-05 00:00:00

abstract：:The Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder characterised both by reproductive and metabolic disturbance, and is the most common cause globally of ovarian infertility. It is also a familial polygenic condition, linked genetically to both Type 2 diabetes and the metabolic syndrome. The striking...

journal_title：Molecular and cellular endocrinology

authors： Corbett S,Morin-Papunen L

更新日期：2013-07-05 00:00:00

abstract：:Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study...

journal_title：Molecular and cellular endocrinology

authors： Kanczkowski W,Chatzigeorgiou A,Samus M,Tran N,Zacharowski K,Chavakis T,Bornstein SR

更新日期：2013-05-22 00:00:00

abstract：:Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart AC,Goosen P,Swart P

更新日期：2013-05-22 00:00:00

abstract：:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in...

journal_title：Molecular and cellular endocrinology

authors： Wang CY,Chen WY,Lai PY,Chung BC

更新日期：2013-05-22 00:00:00

abstract：:The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner mitochondrial membrane for conversion to pregnenolone. Unlike most metabolic pathways, the biosynthesis of adrenocortica...

journal_title：Molecular and cellular endocrinology

authors： Sewer MB,Li D

更新日期：2013-05-22 00:00:00

abstract：:Developmental signalling pathways are implicated in the formation and maintenance of the adrenal gland, but their roles are currently not well defined. In recent years it has emerged that Sonic hedgehog (Shh) and Wnt/β catenin signalling are crucial for the growth and development of the adrenal cortex. Here we demonst...

journal_title：Molecular and cellular endocrinology

authors： Guasti L,Candy Sze WC,McKay T,Grose R,King PJ

更新日期：2013-05-22 00:00:00

abstract：:The mitochondria are critical for steroidogenesis since the ability of cholesterol to move into mitochondria to be available for cytochrome P450, CYP11A1, determines the efficacy of steroid production. Several proteins kinases, such as PKA, MEK and ERK which are essential to complete steroidogenesis, form a mitochondr...

journal_title：Molecular and cellular endocrinology

authors： Poderoso C,Duarte A,Cooke M,Orlando U,Gottifredi V,Solano AR,Lemos JR,Podestá EJ

更新日期：2013-05-22 00:00:00

abstract：:Adipose tissue-derived adipokines play important roles as regulators of skeletal growth and development. CTRP1, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. It is expressed at high levels in adipose tissue and has recently emerged as a novel adipo...

journal_title：Molecular and cellular endocrinology

authors： Akiyama H,Otani M,Sato S,Toyosawa S,Furukawa S,Wakisaka S,Maeda T

更新日期：2013-04-30 00:00:00

abstract：:Gonadotropin-releasing hormone receptor (GnRH-R) activation stimulates synthesis and release of gonadotropins in the vertebrate pituitary and also mediates other processes both in the brain and in peripheral tissues. To better understand the differential function of multiple GnRH-R paralogs, three GnRH-R genes (gnrhr1...

journal_title：Molecular and cellular endocrinology

authors： Peñaranda DS,Mazzeo I,Hildahl J,Gallego V,Nourizadeh-Lillabadi R,Pérez L,Asturiano JF,Weltzien FA

更新日期：2013-04-30 00:00:00